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Dr. Lehmann studies fungi that cause diseases in immunocompromised hosts. His main research has been on development of molecular-genetic methods for fingerprinting fungi for use in studies of epidemiology of hospital-acquired infections, and for taxonomy. In the latter case, the laboratory has shown that a single name may reflect multiple different species and that several species of fungi may be so variable that they are known by more than one name. Recently he has begun to study fungal products that interact with the innate immune response and are involved in inducing immunity to aspergillosis. These receptors are considered to be one of the main routes by which immune cells initially detect a foreign organism. Other interests include lice and poisonous fungi.
Dr. Lehmann received his Ph.D. in 1974 at the University of Cambridge, England. He did postdoctoral work at the University of Birmingham, UK in the departments of Professors Harry Smith (Microbiology) and Philip Gell (Immunology). He then worked with Dr. Errol Reiss in the Mycology Division at the Centers for Disease Control, Atlanta and with Professor Robin Coombs in the Immunology Division at the University of Cambridge, England.
Representative publications:
Lehmann, P.F. (2005) Fungal structure and morphology. In: Merz WG & Hay RJ (eds), Medical Mycology, p. 69-81. In Topley & Wilson's Microbiology and Microbial Infections, 10th edition, London: Hodder Arnold.
Denikus, N., Orfaniotou, F., Wulf, G., Lehmann, P.F., Monod, M. and Reichard, U. (2005) Fungal antigens expressed during invasive aspergillosis. Infect. Immun. 73:4704-4713.
Chen, L.-Y., Doerner, A., Lehmann, P.F., Huang, S., Zhong, G., Pan, Z.K. (2005) A novel protein kinase C (PKC{epsilon}) is required for fMet-Leu-Phe-induced activation of NF-{kappa}B in human peripheral blood monocytes. J. Biol. Chem. 280:22497-22501.
Li, K., Yu, J.-J., Hung, C.-Y., Lehmann, P.F. and Cole, G.T. (2001) Recombinant urease and urease DNA of Coccidioides immitis elicit an immunoprotective response against coccidioidomycosis in mice. Infect. Immun. 69:2878-2887.
Hung, C.-Y., Yu, J.-J., Lehmann, P.F. and Cole, G.T. (2001) Cloning and expression of the gene which encodes a tube precipitin antigen and wall-associated ß-glucosidase of Coccidioides immitis. Infect. Immun. 69: 2211-2222.
San Millan, R.M., Wu, L.-C., Salkin, I.F., and Lehmann, P.F. (1997) Clinical isolates of Candida guilliermondii include Candida fermentati. International Journal of Systematic Bacteriology, 47:385-393.
Zeng, S., Wu, L.C., Lehmann, P.F. (1996) Random amplified polymorphic DNA analysis of culture collection strains of Candida species. Journal of Medical and Veterinary Mycology, 34:293-297.
Lin, D., Lehmann, P.F. (1995) Random amplified polymorphic DNA for strain delineation within Candida tropicalis. Journal of Medical and Veterinary Mycology, 33:241-246.
Lin, D., Wu, L.C., Rinaldi, M.G., Lehmann P.F. (1995) Three distinct genotypes of Candida parapsilosis from clinical sources. J Clinical Microbiology, 33:1815-1821.
Dorf, M.L., Mahler, A.F., Lehmann, P.F. (1994) Incorporating semantics into 2-D strings. Proceedings of the 22nd Annual 1994 ACM Computer Science Conference, March 8-10, Phoenix. In Cizmar, D. (ed.) Scaling Up: Meeting the Challenge of Complexity in Real-World Computing Applications: p. 110-105. New York: Association for Computing Machinery.
Lehmann, P.F., Wu, L.C., Pruitt, W.R., Meyer, S.A., Ahearn, D.G. (1993) Unrelatedness of groups of yeasts within the Candida haemulonii complex. J Clinical Microbiology, 31:1683-1687.
Lehmann, P.F. (1993) Immunity to fungi. - In: Lachmann PJ, Peters DK, Rosen FS, Walport, MJ (ed.), Clinical Aspects of Immunology - 5th Edn., pp.1643-1670 - Blackwell Scientific Publications.
Lehmann, P.F., and Khazan, U. (1992) Mushroom poisoning by Chlorophyllum molybdites in the midwest United States. Cases and a review of the syndrome Mycopathologiz, 118:3-13.
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