Bioinformatics & Proteomics/ Genomics : Genomics Core Lab - Introduction

	Genomics
	David Weaver, DDS, PhD Director, Genomics Core Laboratory (GCL) phone: 419-383-6105 fax: 419-383-3251 email: david.weaver@utoledo.edu

Genomics often refers to comparisons of the entire gene sets between species. At UT, the focus is on which genes are being transcribed in different cells, using microarray equipment. BPG provides students and researchers with the advanced analytical tools and approaches needed for state-of-the-art biomedical research.

Microarrays can track tens of thousands of molecular reactions in parallel to detect specific genes or to measure the activity of genes. The massive amounts of data produced from these studies require "mining" or the systematic application of statistics to determine significant findings.

Suggested Readings

• European Bioinformatics Institute - Microarray Introduction
• Nature - Human Genome Issue (Volume 409, pp 813-959, 2001)
• Science - Human Genome Issue (Volume 291, 2001)
• Nature Genetics - Chipping Forecast (Volume 21 supplement, pp. 1-60, 1999)
• UCLA Practical Guide to Microarray Analysis of Gene Expression

Suggested Sites

• Affymetrix, Inc.
• Stanford University - The Brown Lab
• TIGR - The Institute for Genomic Research
• Oklahoma State University - Microarray Core Facility